Captopril pharmacokinetics [letter]

Effect of Apium graveolens Extract Administration on the Pharmacokinetics of Captopril in the Plasma of Rats

Apium graveolens (celery) is an edible and traditionally medicinal plant that is used worldwide, among others for the treatment of hypertension. Combining celery with antihypertensive drugs can affect the pharmacodynamics and pharmacokinetics of the latter drugs. The aim of the study is to assess the effects of administrating the celery extract on captopril pharmacokinetics. Sprague-Dawley stra...

Dermatitis to captopril.

BACKGROUND reports on delated cutaneous reactions to captopril have been seldom reported. Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur. We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patc...

Captopril: five years on.

Does captopril exacerbate psoriasis?

blood biochemical values were: urea 21-2 mmol/l, creatinine 428 limol/l, sodium 143 mmol/l, chloride 112 mmol/l, potassium 7-2 mmol/l. Muscle cramps due to dehydration and hyperkalaemia were diagnosed and his diuretics and captopril were stopped. He was treated with an insulin-dextrose infusion and calcium resonium. Over the next two days his cramps improved considerably and his serum potassium...

Captopril in hypertensive emergencies.

A 4-year-old girl is presented suffering from severe hypertension due to hemolyticu~emic syndrome. Injection of reserpine and hydralazine was ineffective. Captopril, an oral angiotensin I-converting enzyme inhibitor, showed the dramatic hypotensive effect in our patient.